How should this medicine be used?
Valproic acid comes as a capsule, extended-release
(long-acting) tablet, capsules containing sprinkle medication,
and liquid to take by mouth. It usually is taken two or more
times daily. Follow the directions on your prescription label
carefully, and ask your doctor or pharmacist to explain any
part you do not understand. Take valproic acid exactly as
directed. Do not take more or less of it or take it more often
than prescribed by your doctor.
Do not chew the regular capsules or extended-release
tablets; swallow them whole. Valproic acid has an unpleasant
taste and can irritate your mouth and throat. Take with a full
glass of water.
The sprinkle capsule may be swallowed whole, or the
contents of the capsule may be sprinkled on a teaspoonful of
food, such as applesauce or pudding, and swallowed. Do not
chew the food containing the particles. Do not store unused
food containing sprinkle medication; throw it away and
sprinkle a fresh dose when it is time for the next dose.
Continue to take valproic acid even if you feel well. Do
not stop taking valproic acid without talking to your doctor,
especially if you have taken large doses for a long time.
Abruptly stopping the drug can cause seizures. Your doctor
probably will decrease your dose gradually.
Other uses for this medicine
Valproic acid may be used to treat other types of seizures
in adults and children, incontinence after certain surgical
procedures, and certain anxiety disorders. Talk to your doctor
about the possible risks of using this drug for your
condition.
What special precautions should I follow?
Before taking valproic acid,
* tell your doctor and pharmacist if you are allergic to
valproic acid or any other drugs.
* tell your doctor and pharmacist what prescription and
nonprescription medications you are taking, especially other
seizure medications, anticoagulants ('blood thinners') such as
warfarin (Coumadin), cimetidine (Tagamet), diazepam (Valium),
erythromycin, medications for colds or allergies such as
chlorpheniramine (Chlor-Trimeton), medications for depression
such as amitriptyline (Elavil), medications for pain such as
meperidine (Demerol), muscle relaxants, rifampin (Rifadin),
salicylates such as aspirin, sedatives such as phenobarbital,
tranquilizers such as chlorpromazine (Thorazine), vitamins,
and zidovudine (Retrovir). Valproic acid affects the action of
other medications, and many medications can affect the action
of valproic acid. Tell your doctor and pharmacist everything
you are taking.
* tell your doctor if you have or have ever had liver disease
or a blood disorder.
* tell your doctor if you are breast-feeding.
* if you are having surgery, including dental surgery, tell
the doctor or dentist that you are taking valproic acid.
* you should know that this drug may make you drowsy. Do not
drive a car or operate machinery until you know how this drug
affects you.
* remember that alcohol can add to the drowsiness caused by
this drug.
What special dietary instructions should I follow?
Valproic acid may cause an upset stomach. Take valproic
acid with food. Drink plenty of water. Do not take the liquid
with carbonated beverages.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However,
if you remember a missed dose at the time you are scheduled to
take the next dose, skip the missed dose completely. Do not
take a double dose to make up for a missed one.
What side effects can this medication cause?
Although side effects from valproic acid are not common,
they can occur. Tell your doctor if this symptom is severe or
does not go away:
* drowsiness
* headache
* indigestion
If you experience any of the following symptoms or those
listed in the IMPORTANT WARNING section, call your doctor
immediately:
* skin rash
* easy bruising
* tiny purple-colored skin spots
* bloody nose
* unusual bleeding
* dark urine
* fever
* sore throat
